POLYMERIZATION OF ACROLEIN

Acrolein Reference Exposure Levels

Acrolein is a powerful irritant. Due to its highly reactive nature, the effects of acrolein are generally limited to the site of contact; skin, eyes and mucous membranes. Inhalation exposure to low levels (≤ 1 ppm) causes irritation of the eyes, nose and throat. Acute exposures to levels above 1 ppm result in mucous hypersecretion and exacerbation of allergic airway response in animal models. M...

Acrolein Reference Exposure Levels

Acrolein is a powerful irritant. Due to its highly reactive nature, the effects of acrolein are generally limited to the site of contact; skin, eyes and mucous membranes. Inhalation exposure to low levels (≤ 1 ppm) causes irritation of the eyes, nose and throat. Moderately higher exposures may result in severe lacrimation, and irritation of the mucous membranes of the respiratory tract. Death d...

Mechanism of acrolein-induced vascular toxicity.

Acrolein, an environmental pollutant and a lipid peroxidation product, is implicated in vascular pathogenesis. Although evidence indicates a link between vascular pathogenesis and acrolein, no direct studies relating to effects of acrolein on vascular function and responses are known. This study investigated the effects of acrolein on vascular function to understand the underlying mechanism of ...

Molecular Mechanisms of Acrolein-Mediated Cytotoxicity

FORUM The Molecular Effects of Acrolein

Acrolein is a highly electrophilic a,b-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke. In addition, as a metabolite of cyclophosphamide, acrolein is a major factor in the toxicity and perhaps the therapeutic activity of this important anticancer agent. The exposures to acrolein that are attained in vivo in most sit...